Ethereum hospital
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- Samsung reportedly developing cryptocurrency based on Ethereum
- About The Ether Dome
- Ethereum creator donates meme coins worth $1 billion to help India fight COVID-19
- Ether Hospital Information System
- Back to the Future
- Hotels near ETH-University Hospital Station
- Telangana Health Minister Harish Rao Inaugurates Cath Lab At Khammam Hospital
- China’s Coronavirus Whistleblower Is Now Memorialized on Ethereum
- Hanno Steen, PhD
Samsung reportedly developing cryptocurrency based on Ethereum
ETH Zurich: Liver4Life perfusion machine preserves donor livers for up to one week outside of the body. The demand for donor livers has been growing drastically for years, quickly outstripping the number of organs available.
Every successful liver transplant effectively prolongs the life of a patient. This is why it is important to use all available donor livers optimally. The healthier the liver or partial liver, the better the chances are that the patient will be able to return to a normal life. This is even more likely if it is possible to preserve the donor liver longer outside of the body. And that is exactly what the new perfusion machine does.
With the perfusion machines currently available on the market, donor livers can be preserved for transplantation for a maximum of 24 hours. In order to extend this time, ideally to up to a week, an interdisciplinary team of researchers consisting of surgeons, engineers, and biologists started developing an innovative perfusion machine in mid as part of the Liver4Life project.
It simulates numerous bodily functions and provides a donor liver with an environment that is as similar as possible to the conditions present in a human body. As a result, livers can not only survive up to one week outside of the body, their condition can also be improved considerably, which opens up a variety of new perspectives for future transplants. For example:. Ultimately, the available donor livers can be used much more efficiently as a result, or they are not even required in the first place in the case of an autologous donation.
In order to preserve a liver outside the body, it used to be common practice to pack it in ice, known as static cold storage, to reduce the metabolic processes to a minimum. However, to achieve the goals described above, it is necessary for all biochemical processes in the donor liver to continue as if it were still in the body. For this purpose, the metabolic functions of the liver had to be described in detail from a medical perspective so that engineers could then implement the requirements in a machine.
Five key functions in particular were identified for long-term perfusion: controlling the glucose metabolism, preventing hemolysis the rupture of red blood cells , discharging waste, controlling the supply of oxygen through the perfusate fluid used for the artificial perfusion of organs, blood in this case , and simulating diaphragm movements. In order to maintain the metabolic processes of a donor liver, the functions of various organs have to be simulated by the perfusion machine.
In the human body, the liver is fed through two blood vessels, in which both the blood pressure and the share of oxygen, hormones, and nutrients in the blood vary. Outside of the body, the Liver4Life perfusion machine takes care of all this.
If the donor liver is connected to the machine, it is not simply fed a standard supply of nutrients, neurotransmitters, and oxygen. Waste produced by the liver metabolism is discharged by means of dialysis or as bile. The fluid leaving the liver is fed back into the system. In addition, sensors monitor its condition at all times. What is more, an artificial diaphragm simulates the movements of a real diaphragm to protect the liver from pressure necrosis tissue dying as a result of constant pressure.
Such a setup requires various subcircuits, which all have to be carefully calibrated. The MicroLabBox controls how the sensors and actuators interact with each other. In doing so, it takes over the function of the brain by coordinating the simulation of the different organs.
A MicroLabBox serves as the control unit used to simulate the brain functions required in this context. One of these boxes is being used at ETH Zurich in the field of automotive developments, which means they already had experience using it. The MicroLabBox stood out due to its flexibility and high computing power. The work is supported by the dSPACE experiment software ControlDesk, which makes it possible to access real-time applications while they are running.
As a result, it is possible not only to monitor the supply parameters of the liver but also to influence them actively when a donor organ is connected to the machine. The perfusion machine considerably expands the possibilities of maintaining the metabolic functions of a donor liver outside of the human body. What are the next steps after these promising results? Clinical studies are now required to demonstrate that even mediocre livers can actually be transplanted after undergoing the perfusion process.
The metabolic data delivered by the perfusion machine could provide a reliable evaluation of the organ quality. It would also be conceivable — for example, with cancer patients — to remove healthy parts of the liver, regenerate them in the Liver4Life machine, and retransplant them as a replacement for the diseased organ.
A donor liver would not be required in this case. Thanks to the new perfusion machine, there is a renewed hope that more lives can be saved by making better use of quality donor livers or even with autologous organ donations. The decision as to whether or not a donor organ can be transplanted, for example, has to be definitive and reliable. The perfusion machine, supported by the MicroLabBox, makes it possible to make decisions like this.
University Hospital Zurich, Zurich, Switzerland, Department of Visceral and Transplantation Surgery, contributes his medical expertise to the project team and is responsible for defining the medical requirements. ETH Zurich, Wyss Zurich, Zurich, Switzerland, helped develop the system as part of his dissertation and is responsible for implementing the medical requirements in the machine.
Subscribe newsletter. Subscribe to our newsletters, or manage or delete your subscriptions. With funding from Wyss Zurich, an interdisciplinary group of researchers from ETH Zurich and the University Hospital Zurich has developed a device that significantly extends the life of donor livers outside the human body by simulating a range of bodily functions. A Race Against Time With the perfusion machines currently available on the market, donor livers can be preserved for transplantation for a maximum of 24 hours.
For example: Reliably estimating the quality of the donor livers based on measurement data Improving the quality of previously damaged livers Potentially regenerating parts of a liver in the future Making autologous organ donations possible Ultimately, the available donor livers can be used much more efficiently as a result, or they are not even required in the first place in the case of an autologous donation.
Nature as a Role Model In order to preserve a liver outside the body, it used to be common practice to pack it in ice, known as static cold storage, to reduce the metabolic processes to a minimum.
New Habitat for a Liver In the human body, the liver is fed through two blood vessels, in which both the blood pressure and the share of oxygen, hormones, and nutrients in the blood vary. Simplified diagram of a perfusion machine. Better Simulation for Better Quality The perfusion machine considerably expands the possibilities of maintaining the metabolic functions of a donor liver outside of the human body.
About the authors:. Dilmurodjon Eshmuminov University Hospital Zurich, Zurich, Switzerland, Department of Visceral and Transplantation Surgery, contributes his medical expertise to the project team and is responsible for defining the medical requirements.
Dustin Becker ETH Zurich, Wyss Zurich, Zurich, Switzerland, helped develop the system as part of his dissertation and is responsible for implementing the medical requirements in the machine. MicroLabBox Hardware Compact prototyping unit for the laboratory. Subscribe newsletter Subscribe to our newsletters, or manage or delete your subscriptions. Your partner in simulation and validation.
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About The Ether Dome
A healthcare solution born in an ETH student workshop has now entered mass production: the helpfulETH initiative is supporting hospitals during the coronavirus crisis by producing special face shields. The project has been expanded, and the face shields are now being mass produced. Around 20 hospitals and care facilities have been supplied with masks since March. The global flow of goods was impaired, with some shipments bound for Switzerland even being held up at the borders.
Ethereum creator donates meme coins worth $1 billion to help India fight COVID-19
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Ether Hospital Information System
May 07, Cedars-Sinai Staff. Old-time movie villains used chloroform-soaked rags to subdue their victims, which knocked them out in seconds. The Schimmelbusch mask, invented in and named for its German creator, introduced a portable, hygienic way to put someone under for surgery. Because of its ease of use, it saw military action during World Wars I and II, and it is still used today in some developing countries. Anesthesiologists today employ intravenous medications or gases delivered via a less frightful-looking mask.
Back to the Future
A hospital in China sent the first electronic bill to a patient on its blockchain-based invoice management platform on Monday. The patients can check the immutable medical and billing records for reimbursement without going to the hospital, according to the report. The platform is now only available in the city but it is set to branch out to the rest of the province as the local government is focused on applying blockchain technology to processing official documents for other public institutions. The southern Chinese province has preferential economic policies to lure blockchain companies to open offices in the province. The province capital Haikou is home to some of the leading Chinese blockchain companies, including Huobi China.
Hotels near ETH-University Hospital Station
Padihershef, one of the first complete Egyptian mummies to reach the United States, arrived in as a gift from the City of Boston. Earlier this week, a packed audience in the Ether Dome heard a lecture about Padihershef himself. Tuesday evening, they summarized the process and their results. The recent conservation, funded in part by an anonymous gift, sought to stabilize the 2,year-old specimen and better preserve it for future generations. HMS assistant professor of radiology Rajiv Gupta, who performed the imaging, delivered the medical report, pronouncing the mummy remarkably well preserved.
Telangana Health Minister Harish Rao Inaugurates Cath Lab At Khammam Hospital
ETH Zurich: Liver4Life perfusion machine preserves donor livers for up to one week outside of the body. The demand for donor livers has been growing drastically for years, quickly outstripping the number of organs available. Every successful liver transplant effectively prolongs the life of a patient.
China’s Coronavirus Whistleblower Is Now Memorialized on Ethereum
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Hanno Steen, PhD
By the time the American Civil War broke out in , both ether and chloroform had been in use for several years as methods of surgical anesthesia. Though both anesthetic agents were developed around the same time the s , chloroform soon emerged as the more widely used, as it took action faster and was non-flammable. During the Civil War, ether and particularly chloroform became indispensable tools for military doctors, who performed tens of thousands of amputations and other types of procedures for wounded Union and Confederate soldiers. Before its development as a surgical anesthetic, ether was used throughout the history of medicine, including as a treatment for ailments such as scurvy or pulmonary inflammation. A pleasant-smelling, colorless and highly flammable liquid, ether can be vaporized into a gas that numbs pain but leaves patients conscious. In , Georgia physician Crawford Williamson Long became the first doctor to use ether as a general anesthetic during surgery, when he used it to remove a tumor from the neck of his patient James M.
In the small town of Jefferson, Georgia, about 20 miles from the University of Georgia in Athens, a year-old physician named Crawford Williamson Long removed a tumor from the neck of a man named James Venable while Venable was anesthetized with ether. The date was March 30, More than four years later, in Boston, Massachusetts, on Oct.
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